Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Objective: Acute kidney injury requiring renal replacement therapy in severe vasodilatory
shock is associated with an unfavorable prognosis. Angiotensin II treatment may help these …

AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …

The acute loss of kidney function has been diagnosed for many decades using the serum
concentration of creatinine—a muscle metabolite that is an insensitive and non-specific …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

After fluid administration for vasodilatory shock, vasopressors are commonly infused.
Causes of vasodilatory shock include septic shock, post-cardiovascular surgery, post-acute …