Diet-induced gut barrier dysfunction is exacerbated in mice lacking cannabinoid 1 receptors in the intestinal epithelium

MB Wiley, NV DiPatrizio - International Journal of Molecular Sciences, 2022 - mdpi.com
The gut barrier provides protection from pathogens and its function is compromised in diet-
induced obesity (DIO). The endocannabinoid system in the gut is dysregulated in DIO and …

Multi metabolomics-based analysis of application of Astragalus membranaceus in the treatment of hyperuricemia

W Zhang, Y Cui, J Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Hyperuricemia (HUA) is a common metabolic disease that is an independent risk factor for
comorbidities such as hypertension, chronic kidney disease, and coronary artery disease …

The 16α-hydroxylated Bile Acid, Pythocholic Acid Decreases Food Intake and Increases Oleoylethanolamide in Male Mice

S Higuchi, C Wood, RH Nasiri, LJ Giddla… - …, 2023 - academic.oup.com
Modulation of bile acid (BA) structure is a potential strategy for obesity and metabolic
disease treatment. BAs act not only as signaling molecules involved in energy expenditure …

The Regulation Network of Glycerolipid Metabolism as Coregulators of Immunotherapy‐Related Myocarditis

X Yang, X Duan, Z Xia, R Huang, K He… - Cardiovascular …, 2023 - Wiley Online Library
Background. To date, immunotherapy for patients with malignant tumors has shown a
significant association with myocarditis. However, the mechanism of metabolic …

Cholinergic neurotransmission controls orexigenic endocannabinoid signaling in the gut in diet-induced obesity

CP Wood, C Alvarez, NV DiPatrizio - Journal of Neuroscience, 2024 - Soc Neuroscience
The brain bidirectionally communicates with the gut to control food intake and energy
balance, which becomes dysregulated in obesity. For example, endocannabinoid (eCB) …

Docosahexaenoic Acid Modulates Nonalcoholic Fatty Liver Disease by Suppressing Endocannabinoid System

Y Chen, Z Fan, Y Wang, P Liu… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Endocannabinoid signaling regulates energy homeostasis, and is tightly associated
with nonalcoholic fatty liver disease (NAFLD). The study previously finds that …

Effects of selective breeding, voluntary exercise, and sex on endocannabinoid levels in the mouse small-intestinal epithelium

MP Schmill, Z Thompson, DA Argueta… - Physiology & …, 2022 - Elsevier
The endocannabinoid (eCB) system in the gut communicates with the body and brain as
part of the homeostatic mechanisms that affect energy balance. Although perhaps best …

Isolation and Quantification of the Hepatoprotective Flavonoids From Scleromitron diffusum (Willd.) RJ Wang With Bio-Enzymatic Method Against NAFLD by UPLC …

Y Qin, B Zhao, H Deng, M Zhang, Y Qiao… - Frontiers in …, 2022 - frontiersin.org
Flavonoids were the major phytochemicals against hepatic peroxidative injury in
Scleromitron diffusum (Willd.) RJ Wang with an inventive bio-enzymatic method by our …

The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases jejunal fatty acid ethanolamides in mice

S Higuchi, C Wood, NV DiPatrizio, A Kawamura… - bioRxiv, 2022 - biorxiv.org
Objective Modulation of bile acid (BA) structure is a potential strategy for obesity and
metabolic disease treatment. BAs act not only as signaling molecules involved in energy …

Endocannabinoid modulation of astroglial cells in multiple sclerosis

ÁM García - 2022 - theses.hal.science
Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory disease of the central
nervous system and a leading cause of disability in young adults. It is well-established that …