Microbiome in colorectal cancer: how to get from meta-omics to mechanism?

D Ternes, J Karta, M Tsenkova, P Wilmes, S Haan… - Trends in …, 2020 - cell.com
Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

Colon cancer: from epidemiology to prevention

K Katsaounou, E Nicolaou, P Vogazianos, C Brown… - Metabolites, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …

[HTML][HTML] Gut microbiota modulate CD8 T cell responses to influence colitis-associated tumorigenesis

IY Amy, L Zhao, KA Eaton, S Ho, J Chen, S Poe… - Cell reports, 2020 - cell.com
There is increasing evidence that gut microbiome perturbations, also known as dysbiosis,
can influence colorectal cancer development. To understand the mechanisms by which the …

[HTML][HTML] Macrophages maintain epithelium integrity by limiting fungal product absorption

AS Chikina, F Nadalin, M Maurin, M San-Roman… - Cell, 2020 - cell.com
The colon is primarily responsible for absorbing fluids. It contains a large number of
microorganisms including fungi, which are enriched in its distal segment. The colonic …

The developing story of predictive biomarkers in colorectal cancer

S Boussios, MA Ozturk, M Moschetta… - Journal of personalized …, 2019 - mdpi.com
Colorectal cancer (CRC) is the third most common malignancy worldwide. Surgery remains
the most important treatment for non-metastatic CRC, and the administration of adjuvant …

Giardia spp. and the Gut Microbiota: Dangerous Liaisons

E Fekete, T Allain, A Siddiq, O Sosnowski… - Frontiers in …, 2021 - frontiersin.org
Alteration of the intestinal microbiome by enteropathogens is commonly associated with
gastrointestinal diseases and disorders and has far-reaching consequences for overall …

Colon cancer in young adults: trends and their implications

BA Weinberg, JL Marshall - Current Oncology Reports, 2019 - Springer
Abstract Purpose of Review The recent rise of young individuals under age 50 with
colorectal cancer (CRC) is a startling trend in need of greater focus and research. The …

Risk factor profiles differ for cancers of different regions of the colorectum

L Wang, CH Lo, X He, D Hang, M Wang, K Wu… - Gastroenterology, 2020 - Elsevier
Background & Aims The molecular features of colorectal tumors differ with their anatomic
location. Colorectal tumors are usually classified as proximal or distal. We collected data …

No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population

LW Hugerth, A Andreasson, NJ Talley, AM Forsberg… - Gut, 2020 - gut.bmj.com
Objective The ethiopathogenesis of irritable bowel syndrome (IBS) is unknown. While a link
to the gut microbiome is postulated, the heterogeneity of the healthy gut makes it difficult to …

Comparison of gut microbiome composition in colonic biopsies, endoscopically-collected and at-home-collected stool samples

C Nowicki, L Ray, P Engen, A Madrigrano… - Frontiers in …, 2023 - frontiersin.org
Aim The goal of this study is to compare microbiome composition in three different sample
types in women, namely stool brought from home vs. solid stool samples obtained at the …