Plasminogen is an abundant plasma protein that exists in various zymogenic forms.
Plasmin, the proteolytically active form of plasminogen, is known for its essential role in …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty
acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4 …

Background Previous studies have suggested that desmoteplase, a novel plasminogen
activator, has clinical benefit when given 3–9 h after the onset of the symptoms of stroke in …

NEURONAL degeneration in the hippocampus, a region of the brain important for
acquisition of memory in humans, occurs in various pathological conditions, including …

Amyloid-β (Aβ) appears critical to Alzheimer's disease. To clarify possible mechanisms of Aβ
action, we have quantified Aβ-induced gene expression in vitro by using Aβ-treated primary …

Extensive β‐amyloid (Aβ) deposits in brain parenchyma in the form of senile plaques and in
blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer′ s …

Accumulation of the amyloid-β (Aβ) peptide depends on both its generation and clearance.
To better define clearance pathways, we have evaluated the role of the tissue plasminogen …

The accumulation of Aβ (amyloid β-protein) peptides in the brain is a pathological hallmark
of all forms of AD (Alzheimer's disease) and reducing Aβ levels can prevent or reverse …

Intracerebral haemorrhage is a complication of thrombolytic therapy for acute myocardial
infarction, pulmonary embolism, and ischaemic stroke. There is increasing evidence that …