Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
Y Feng, Y Xiong, T Qiao, X Li, L Jia, Y Han - Cancer medicine, 2018 - Wiley Online Library
Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …
'Warburg effect'controls tumor growth, bacterial, viral infections and immunity–Genetic deconstruction and therapeutic perspectives
The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …
MYC, metabolism, and cancer
The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
The mechanism of Warburg effect-induced chemoresistance in cancer
C Liu, Y Jin, Z Fan - Frontiers in oncology, 2021 - frontiersin.org
Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …
The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor
CJ Valvona, HL Fillmore, PB Nunn… - Brain …, 2016 - Wiley Online Library
There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …
Unappreciated role of LDHA and LDHB to control apoptosis and autophagy in tumor cells
K Urbańska, A Orzechowski - International journal of molecular sciences, 2019 - mdpi.com
Tumor cells possess a high metabolic plasticity, which drives them to switch on the
anaerobic glycolysis and lactate production when challenged by hypoxia. Among the …
anaerobic glycolysis and lactate production when challenged by hypoxia. Among the …
[HTML][HTML] The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment
The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …
progression and includes the surrounding stromal and immune cells, extracellular matrix …
MYC, metabolism, cell growth, and tumorigenesis
CV Dang - Cold Spring Harbor perspectives in …, 2013 - perspectivesinmedicine.cshlp.org
The MYC proto-oncogene is frequently activated in human cancers through a variety of
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …
Role of mitochondrial membrane potential and lactate dehydrogenase a in apoptosis
Apoptosis is a programmed cell death that occurs due to the production of several catabolic
enzymes. During this process, several morphological and biochemical changes occur in …
enzymes. During this process, several morphological and biochemical changes occur in …
Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate
and lactate, is upregulated in human cancers, and is associated with aggressive tumor …
and lactate, is upregulated in human cancers, and is associated with aggressive tumor …