Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

There is a large interindividual variability in response to ICSs in asthma. About 70% of the
variance in ICS response is likely due at least partially to genetically determined …

Background Genetic associations of the response to inhaled corticosteroids (ICS s) during
an asthma exacerbation are unknown. Objective To evaluate the role of genetic variants in …

Introduction TGF-β and its receptors play a crucial role in asthma pathogenesis and
bronchial remodeling in the course of the disease. TGF-β1, TGF-β2, and TGF-β3 isoforms …

Glucocorticosteroids (GCs) are basic drugs in therapy of a number of diseases, including
chronic diseases of the respiratory system. They are the most important anti-inflammatory …

Background: Glucocorticoid receptor gene polymorphism (NR3C1 646 C> G) may play an
important role in the development of severe bronchial asthma and resistance to …

Acute myeloid leukemia (AML) is a complex hematological neoplasm with poor prognosis.
At present, overwhelming evidence indicates that different genetic abnormalities are …

Chronic inflammation in the bronchi of long-term asthma patients worsens mood disorders,
which has been shown to correlate with elevated levels of multiple proinflammatory …

Background Exploring the pathogenetic mechanisms behind severe lung damage in COVID-
19 is crucial. In this study, we decided to focus on two molecular markers that affect …

Polymorphisms of the NR3C1 (glucocorticoid receptor) gene have been reported to be
associated with altered glucocorticoids sensitivity and changes in body composition and …