Foundations of gastrointestinal-based drug delivery and future developments

JN Chu, G Traverso - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

[HTML][HTML] Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

DJ Brayden, TA Hill, DP Fairlie, S Maher… - Advanced drug delivery …, 2020 - Elsevier
In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics
especially peptides and proteins. In the intervening period, analysis of the preclinical and …

[HTML][HTML] Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Z Vinarov, B Abrahamsson, P Artursson… - Advanced Drug Delivery …, 2021 - Elsevier
Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Oral delivery of biologics for precision medicine

M Durán‐Lobato, Z Niu, MJ Alonso - Advanced Materials, 2020 - Wiley Online Library
The emerging field of precision medicine is rapidly growing, fostered by the advances in
genome mapping and molecular diagnosis. In general, the translation of these advances …

Oral insulin delivery platforms: strategies to address the biological barriers

Y Xiao, Z Tang, J Wang, C Liu, N Kong… - Angewandte Chemie …, 2020 - Wiley Online Library
Diabetes mellitus is a lifelong metabolic disease that requires frequent subcutaneous
injections of insulin. However, this method of administration can be associated with patient …

Modification of chitosan using amino acids for wound healing purposes: A review

S Torkaman, H Rahmani, A Ashori, SHM Najafi - Carbohydrate polymers, 2021 - Elsevier
Chitosan, a well-known biopolymer due to its unique properties, has received considerable
attention as a result of the amine group activity that locates on the backbone of chitosan. To …

[HTML][HTML] Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Y Han, Z Gao, L Chen, L Kang, W Huang, M Jin… - … Pharmaceutica Sinica B, 2019 - Elsevier
In last few years, therapeutic peptides/proteins are rapidly growing in drug market
considering their higher efficiency and lower toxicity than chemical drugs. However, the …

Polymer-based nanoparticle strategies for insulin delivery

S Mansoor, PPD Kondiah, YE Choonara, V Pillay - Polymers, 2019 - mdpi.com
Diabetes mellitus (DM) is a chronic metabolic illness estimated to have affected 451 million
individuals to date, with this number expected to significantly rise in the coming years. There …

Oral peptide delivery: Translational challenges due to physiological effects

P Tyagi, S Pechenov, JA Subramony - Journal of Controlled Release, 2018 - Elsevier
Oral delivery of peptide therapeutics as a convenient alternate to injections has been an
area of research for the pharmaceutical scientific community for the last several decades …

Burgeoning polymer nano blends for improved controlled drug release: a review

S Maghsoudi, B Taghavi Shahraki… - International Journal …, 2020 - Taylor & Francis
With continual rapid developments in the biomedical field and understanding of the
important mechanisms and pharmacokinetics of biological molecules, controlled drug …