While ovarian cancer typically responds well to front line treatment, many patients will
relapse within 5 years. Treatment options are less effective at each recurrence highlighting …

Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation,
tumorigenesis, and anti-cancer drug resistance. Overexpression and somatic mutations of …

DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kDa GTPase with 60%
amino acid homology to RAS, but with a distinctive 34 amino acid N-terminal extension …

Although Parkinson's disease (PD) is the second most common neurodegenerative
disorder, the preventative or therapeutic agents for the treatment of PD are limited …

Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …

For many years, it was thought that ATG5 and ATG7 played a pivotal role in autophagy, and
that the knockdown of one of these genes would result in its inhibition. However, cells with …

Ovarian cancer is the most deadly gynecologic malignancy, and its incidence is gradually
increasing. Despite improvements after treatment, the results are unsatisfactory and survival …

Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs),
which seed metastasis, can remain undetected in a dormant state for decades after …

Hydroxysafflor yellow A (HSYA) is a water‑soluble component of the safflower (Carthamus
tinctorius), and research has revealed that HSYA exhibits antitumor effects. In the present …

Programmed cell death (PCD) is a fundamental process in the development process of
organisms, including apoptosis, autophagy, ferroptosis, and pyroptosis. In mammalian …