BACKGROUND: The association between the inherited gene mutations of factor V,
prothrombin, and homocysteine metabolism and venous thromboembolic events is accepted …

BACKGROUND AND OBJECTIVE: Venous thrombosis is a common disease annually
affecting 1 in 1000 individuals. The multifactorial nature of the disease is illustrated by the …

Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors
involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case …

We have investigated the influence of alterations in plasma coagulation factor levels
between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX …

Background—A single base pair mutation in the prothrombin gene has recently been
identified that is associated with increased prothrombin levels. Whether this mutation …

Background: Osteonecrosis has been reported to occur occasionally among HIV-infected
patients. The diagnosis of symptomatic osteonecrosis of the hip in two of the authors' …

Background—It is pathophysiologically conceivable that genetic variations in coagulation
and fibrinolytic proteins are associated with the risk of myocardial infarction. Methods and …

The inherited thrombophilias—deficiencies of protein C, protein S, and antithrombin III—and
the prothrombotic polymorphisms factor V G1691A and factor II G20210A predispose …

Single-point mutations in the gene coding for prothrombin (factor II: A20210) or factor V
(factor V: A1691) are associated with an increased risk of venous thromboembolism. The …

Background—Hypercoagulable states are a recognized, albeit uncommon, etiology of
ischemic stroke. It is unclear how often the results of specialized coagulation tests affect …