FCGR2A/FCGR3A gene polymorphisms and clinical variables as predictors of response to tocilizumab and rituximab in patients with rheumatoid arthritis

A Jiménez Morales… - The Journal of …, 2019 - Wiley Online Library
We evaluated the influence of clinical, biochemical, and genetic factors on response in 142
patients diagnosed with rheumatoid arthritis, of whom 87 patients were treated with …

Influence of IL6R gene polymorphisms in the effectiveness to treatment with tocilizumab in rheumatoid arthritis

M Maldonado-Montoro, M Cañadas-Garre… - The …, 2018 - nature.com
In the present study, we aimed to investigate the influence of clinical parameters and single-
nucleotide polymorphisms of interleukin-6 receptor (rs12083537, rs2228145, rs4329505 …

Genetic and clinical biomarkers of tocilizumab response in patients with rheumatoid arthritis

M Maldonado-Montoro, M Cañadas-Garre… - Pharmacological …, 2016 - Elsevier
The aim of this study was to investigate the influence of clinical and genetic factors on
response to tocilizumab (TCZ) response, remission, low disease activity (LDA) and DAS28 …

Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer …

C Perez-Ramirez, M Canadas-Garre… - The …, 2019 - nature.com
Chemotherapy based on platinum compounds is the standard treatment for NSCLC patients
with EGFR wild type, and is also used as second line in mutated EGFR patients …

Pharmacogenetic predictors of toxicity to platinum based chemotherapy in non-small cell lung cancer patients

C Perez-Ramirez, M Canadas-Garre, A Alnatsha… - Pharmacological …, 2016 - Elsevier
Platinum-based chemotherapy is the standard treatment for NSCLC patients with EGFR wild-
type, and as alternative to failure to EGFR inhibitors. However, this treatment is aggressive …

[HTML][HTML] Pharmacogenetics aspects of oral anticoagulants therapy

FC Militaru, SC Vesa, TR Pop… - Journal of medicine and …, 2015 - ncbi.nlm.nih.gov
Abstract Rationale: Vitamin K antagonists (VKA), such as warfarin and acenocoumarol, are
widely used for the prevention and treatment of thromboembolic diseases and they are …

Interleukins as new prognostic genetic biomarkers in non-small cell lung cancer

C Perez-Ramirez, M Canadas-Garre, A Alnatsha… - Surgical Oncology, 2017 - Elsevier
Background Surgery is the standard treatment for early-stage NSCLC, and platinum-based
chemotherapy remains as the treatment of choice for advanced-stage NSCLC patients with …

Association of ABCB1 and VEGFA gene polymorphisms with breast cancer susceptibility and prognosis

A Madrid-Paredes, MÁ Casado-Combreras… - … -Research and Practice, 2020 - Elsevier
Breast cancer (BC) is the most common cause of cancer-related death in women worldwide.
Several ABCB1 and VEGFA gene polymorphisms, such as ABCB1-G1199 T/A (rs2229109) …

[HTML][HTML] Pharmacogenetic predictors of response to interferon beta therapy in multiple sclerosis

MI Carrasco-Campos, C Pérez-Ramírez… - Molecular …, 2021 - Springer
First-line therapy with interferon beta (IFN-β), involved in gene expression modulation in
immune response, is widely used for multiple sclerosis. However, 30–50% of patients do not …

A predictive nomogram for short‐term outcomes of myasthenia gravis patients treated with low‐dose rituximab

Y Zhou, R Guo, X Xia, S Jing, J Lu… - CNS Neuroscience …, 2024 - Wiley Online Library
Background This study aims to establish and validate a predictive nomogram for the short‐
term clinical outcomes of myasthenia gravis (MG) patients treated with low‐dose rituximab …