Introduction: The cost of in vivo and in vitro screening of ADME properties of compounds has
motivated efforts to develop a range of in silico models. At the heart of the development of …

Purpose The goal was to assess, for lipophilic drugs, the impact of logP on human volume of
distribution at steady-state (VDss) predictions, including intermediate fut and Kp values, from …

Little is known about the uptake of drugs into the human heart, although it is of great
importance nowadays, when science desires to predict tissue level behavior rather than to …

Purpose To develop a QSAR model, based on calculated molecular descriptors and an
Artificial Neural Networks Ensemble (ANNE), for the estimation of rat tissue-to-blood partition …

The adipose tissue: blood partition coefficient is a key‐endpoint to predict the
pharmacokinetics of chemicals in humans and animals, since other organ: blood affinities …

In this work it is shown that when a carbon paste electrode, CPE, is modified with a β-
cyclodextrin polymer, the tenoxicam oxidation becomes an adsorption controlled process …

Analysis of the partition coefficients of small organic compounds and proteins in different
aqueous two-phase systems under widely varied ionic compositions shows that logarithms …

The number of poorly water-soluble drugs in the pipeline has increased, and they are often
not well absorbed by the gastrointestinal tract. Amorphous solid dispersion (ASD) is an …

Partition coefficients of non-ionic essentially nonpolar compounds between air and rat
biological tissues and between blood and other tissues were examined and found to be …

This thesis describes a series of experimental studies (in vitro, ex vivo, in vivo) conducted
and integrated using modelling/scaling approaches to develop compartmental and …