The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Atherosclerotic cardiovascular disease (CVD), the major cause of premature human
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …

Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

Prolonged lung pathology has been associated with COVID-19, yet the cellular and
molecular mechanisms behind this chronic inflammatory disease are poorly understood. In …

Atherosclerosis is a fundamental disease of the cardiovascular system that leads to high
morbidity and mortality worldwide. The endothelium is the first protective barrier in …

Diabetes and its complications represent a great burden on the global healthcare system.
Diabetic complications are fundamentally diseases of the vasculature, with endothelial cells …

Background: The inhibition of histone deacetylase 9 (HDAC9) represents a promising
druggable target for stroke intervention. Indeed, HDAC9 is overexpressed in neurons after …

The physiological functions of endothelial cells control vascular tone, permeability,
inflammation, and angiogenesis, which significantly help to maintain a healthy vascular …