Dendritic spine pathology in schizophrenia

JR Glausier, DA Lewis - Neuroscience, 2013 - Elsevier
Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies

RG Steen, C Mull, R Mcclure, RM Hamer… - The British Journal of …, 2006 - cambridge.org
BackgroundStudies of people with schizophrenia assessed using magnetic resonance
imaging (MRI) usually include patients with first-episode and chronic disease, yet brain …

Accelerated brain aging in schizophrenia: a longitudinal pattern recognition study

HG Schnack, NEM Van Haren… - American Journal of …, 2016 - Am Psychiatric Assoc
Objective: Despite the multitude of longitudinal neuroimaging studies that have been
published, a basic question on the progressive brain loss in schizophrenia remains …

The neurobiology and treatment of first-episode schizophrenia

RS Kahn, IE Sommer - Molecular psychiatry, 2015 - nature.com
It is evident that once psychosis is present in patients with schizophrenia, the underlying
biological process of the illness has already been ongoing for many years. At the time of …

Neuroimaging predictors of transition to psychosis—a systematic review and meta-analysis

R Smieskova, P Fusar-Poli, P Allen, K Bendfeldt… - Neuroscience & …, 2010 - Elsevier
OBJECTIVES: In early stage psychosis research the identification of neurobiological
correlates of vulnerability to schizophrenia is an important hurdle. METHODS: We …

Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia

KH Karlsgodt, TGM van Erp, RA Poldrack… - Biological …, 2008 - Elsevier
BACKGROUND: Structural and functional abnormalities in frontal-parietal circuitry are
thought to be associated with working memory (WM) deficits in patients with schizophrenia …

Brain volumes in relatives of patients with schizophrenia: a meta-analysis

HBM Boos, A Aleman, W Cahn, HH Pol… - Archives of general …, 2007 - jamanetwork.com
Context Smaller brain volumes have consistently been found in patients with schizophrenia,
particularly in gray matter and medial temporal lobe structures. Although several studies …

Association of genetic risks for schizophrenia and bipolar disorderwith specific and generic brain structural endophenotypes

C McDonald, ET Bullmore, PC Sham… - Archives of general …, 2004 - jamanetwork.com
Context For more than a century, it has been uncertain whether or not the major diagnostic
categories of psychosis—schizophrenia and bipolar disorder—are distinct disease entities …

Regional gray matter volume abnormalities in the at risk mental state

SJ Borgwardt, A Riecher-Rössler, P Dazzan… - Biological …, 2007 - Elsevier
BACKGROUND: Individuals with an At Risk Mental State (ARMS) have a very high risk of
developing a psychotic disorder but the basis of this risk is unclear. We addressed this issue …

Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function

DC Glahn, PM Thompson, J Blangero - Human brain mapping, 2007 - Wiley Online Library
It is vitally important to identify the genetic determinants of complex brain‐related disorders
such as autism, dementia, mood disorders, and schizophrenia. However, the search for …