Advances in our understanding of the biology of spinal systems in organizing and defining
the content of exteroceptive information upon which higher centers define the state of the …

Cancer-related pain is a common and debilitating condition that can significantly affect the
quality of life of patients. Opioids, NSAIDs, and antidepressants are among the first-line …

Objectives Recent recommendations on starting dose, smaller dose increments, and longer
intervals between dose increase have the potential to increase the safety of ziconotide …

Older people often suffer from different types of ulcers, with the most prevalent being chronic
leg ulcers (CLUs) and diabetic foot ulcers. There are major issues in the current medical …

Purpose Most oncological treatments for leptomeningeal metastasis (LM) do not cross the
blood-brain barrier (BBB). One therapeutic option is intrathecal (IT) chemotherapy. Both the …

Pain and suffering related to cancer are challenging issues that continue to deserve
consideration for treatment optimization. Advances in analgesic management and control of …

Objective Targeted drug delivery (TDD) via intrathecal drug delivery systems (IDDS)
exposure and clinical adoption remains low despite multiple well-designed trials that …

The British Pain Society updated their recommendations on intrathecal drug delivery (ITDD)
for the management of pain and spasticity in adults. The recommendations are primarily …

Background/Aim: The study aim was to analyze the feasibility and efficacy of palliative
radiotherapy in patients receiving advanced/interventional pain therapy, such as epidural or …

Background In cancer patients with limited life expectancy, an implant of an intrathecal (IT)
drug delivery system connected to a subcutaneous port (IDDS-SP) has been proposed as a …