Phytic acid: Blessing in disguise, a prime compound required for both plant and human nutrition
Abstract Phytic acid (PA),[myo-inositol 1, 2, 3, 4, 5, 6-hexakisphosphate] is the principal
storage compound of phosphorus (P) and account for 65%–85% of the seeds total P. The …
storage compound of phosphorus (P) and account for 65%–85% of the seeds total P. The …
[HTML][HTML] Regulation of obesity and insulin resistance by nitric oxide
BE Sansbury, BG Hill - Free radical biology and medicine, 2014 - Elsevier
Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …
quickly become a worldwide pandemic with few tangible and safe treatment options …
[HTML][HTML] Single-nucleus and in situ RNA–sequencing reveal cell topographies in the human pancreas
Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …
pancreas has not been yet established, due to the local concentration and cascade of …
Integrating the inputs that shape pancreatic islet hormone release
GM Noguchi, MO Huising - Nature Metabolism, 2019 - nature.com
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …
their support cells, which together tightly control blood glucose homeostasis. Changes in …
Impact of islet architecture on β-cell heterogeneity, plasticity and function
SS Roscioni, A Migliorini, M Gegg… - Nature Reviews …, 2016 - nature.com
Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …
principles have been explored only during the past decade. Islet-cell heterogeneity arises …
Practical guide to exocrine pancreatic insufficiency–breaking the myths
MR Struyvenberg, CR Martin, SD Freedman - BMC medicine, 2017 - Springer
Background Exocrine pancreatic insufficiency (EPI) is characterized by a deficiency of
exocrine pancreatic enzymes, resulting in malabsorption. Numerous conditions account for …
exocrine pancreatic enzymes, resulting in malabsorption. Numerous conditions account for …
Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis
Acute pancreatitis (AP), an acute inflammatory disorder of the exocrine pancreas, is one of
the most common gastrointestinal diseases encountered in emergency departments with no …
the most common gastrointestinal diseases encountered in emergency departments with no …
Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma
Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet
how and when obesity contributes to PDAC progression is not well understood. Leveraging …
how and when obesity contributes to PDAC progression is not well understood. Leveraging …
Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer
AC Mutgan, HE Besikcioglu, S Wang, H Friess… - Molecular cancer, 2018 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal
cancer in the western world. There is substantial evidence implying that insulin and insulin …
cancer in the western world. There is substantial evidence implying that insulin and insulin …
Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression
RE Stamateris, RB Sharma… - American Journal of …, 2013 - journals.physiology.org
Type 2 diabetes (T2D) is caused by relative insulin deficiency, due in part to reduced β-cell
mass (,). Therapies aimed at expanding β-cell mass may be useful to treat T2D. Although …
mass (,). Therapies aimed at expanding β-cell mass may be useful to treat T2D. Although …