Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits

NL Cerminara, EJ Lang, RV Sillitoe… - Nature Reviews …, 2015 - nature.com
The adult mammalian cerebellar cortex is generally assumed to have a uniform
cytoarchitecture. Differences in cerebellar function are thought to arise primarily through …

The cerebellar cortex

C Hull, WG Regehr - Annual review of neuroscience, 2022 - annualreviews.org
The cerebellar cortex is an important system for relating neural circuits and learning. Its
promise reflects the longstanding idea that it contains simple, repeated circuit modules with …

Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

H Fujita, T Kodama, S Du Lac - Elife, 2020 - elifesciences.org
The cerebellar vermis, long associated with axial motor control, has been implicated in a
surprising range of neuropsychiatric disorders and cognitive and affective functions …

Timing rules for synaptic plasticity matched to behavioral function

A Suvrathan, HL Payne, JL Raymond - Neuron, 2016 - cell.com
It is widely assumed that the complexity of neural circuits enables them to implement diverse
learning tasks using just a few generic forms of synaptic plasticity. In contrast, we report that …

Purkinje cell microzones mediate distinct kinematics of a single movement

FGC Blot, JJ White, A van Hattem, L Scotti… - nature …, 2023 - nature.com
The classification of neuronal subpopulations has significantly advanced, yet its relevance
for behavior remains unclear. The highly organized flocculus of the cerebellum, known to …

Roles of aldolase family genes in human cancers and diseases

YC Chang, YC Yang, CP Tien, CJ Yang… - Trends in Endocrinology & …, 2018 - cell.com
The aldolase family members involved in metabolism and glycolysis are present in three
isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human …

Neuronal and glial cell number is altered in a cortical layer-specific manner in autism

C Falcone, NY Mevises, T Hong, B Dufour, X Chen… - …, 2021 - journals.sagepub.com
Autism spectrum disorder is a neurodevelopmental condition characterized by impaired
social communication and repetitive behaviors. Changes in the number of specific cell types …

TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

B Wu, FGC Blot, AB Wong, C Osorio, Y Adolfs… - Elife, 2019 - elifesciences.org
Despite the canonical homogeneous character of its organization, the cerebellum plays
differential computational roles in distinct sensorimotor behaviors. Previously, we showed …

Purkinje cell-specific knockout of tyrosine hydroxylase impairs cognitive behaviors

TM Locke, H Fujita, A Hunker, SS Johanson… - Frontiers in cellular …, 2020 - frontiersin.org
Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs)
of rodents and humans, but its role in the regulation of behavior is not understood …

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

GC Beekhof, C Osório, JJ White, S van Zoomeren… - Elife, 2021 - elifesciences.org
Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features
are at the core of the modular organization of the cerebellum. Previously, we showed that …