In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Monoclonal antibodies (mAbs) are a fast-growing class of biopharmaceuticals. They are
widely used in the identification and detection of cell makers, serum analytes, and …

The higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality
attribute with strong contribution to clinically relevant biological functions and drug safety …

This review highlights recent advancements in using high resolution nuclear magnetic
resonance (NMR) spectroscopy as a characterization tool to expedite biologics formulation …

A review of the literature published from January to December 2019 on theoretical aspects
of nuclear magnetic shielding is presented. It covers both non-relativistic and relativistic …

Obtaining high ordered structure (HOS) information is of importance to guarantee the
efficacy and safety of monoclonal antibodies (mAbs) in clinical application. Assessment of …

A primary biological function of multi-spanning membrane proteins is to transfer information
and/or materials through a membrane by changing their conformations. Therefore, particular …

Resonance assignment signifies the process through which an NMR signal at a certain
resonance frequency, or chemical shift, is correlated to a specific atom in a protein. The …

The intracellular environment is highly crowded (molecular crowding) and differs
significantly from the environment in dilute solutions that we usually use in biochemical …

The unique strength of solution-state nuclear magnetic resonance (NMR) is to contribute not
only to determine high-resolution structures of macromolecules but also to provide …