The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

INTRODUCTION In Alzheimer's disease (AD), the production of amyloid β (Aβ) oligomers
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …

The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …

Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an
occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We …

Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …

Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …