Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …

Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These
proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell …

Cultivation of filamentous fungi to produce sustainable, nutrient rich meat replacements has
recently attracted significant commercial and research interest. Here, we report evidence for …

Disintegrins are a family of cysteine-rich small proteins that were first identified in snake
venom. The high divergence of disintegrins gave rise to a plethora of functions, all related to …

Cancer cells exhibit molecular characteristics that confer them different proliferative
capacities and survival advantages to adapt to stress conditions, such as deregulation of …

Significance: Oxidative stress in the cell is characterized by excessive generation of reactive
oxygen species (ROS). Superoxide (O2−) and hydrogen peroxide (H2O2) are the main ROS …

Snake venoms consist of a complex mixture of many bioactive molecules. Among them are
disintegrins, which are peptides without enzymatic activity, but with high binding affinity for …

Integrins are a large family of heterodimeric transmembrane receptors which mediate cell
adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have …

Disintegrins are small peptides possessing a tripeptide motif capable of binding to integrins.
These were first isolated from viper venoms and are now also found in many other …