Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Until recently, our understanding of the genetic factors contributing to the pathogenesis of
acute lymphoblastic leukemia (ALL) has relied on the detection of gross chromosomal …

Because of their somatic cell origin, human induced pluripotent stem cells (HiPSCs) are
assumed to carry a normal diploid genome, and adaptive chromosomal aberrations have …

Tumor suppressor p53 plays a central role in tumor prevention. p53 protein levels and
activity are under a tight and complex regulation in cells to maintain the proper function of …

Background Acute myeloid leukemia (AML) remains one of the most common hematological
malignancies, posing a serious challenge to human health. HSPA8 is a chaperone protein …

Abstract ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …

Over the years, methods of cytogenetic analysis evolved and became part of routine
laboratory testing, providing valuable diagnostic and prognostic information in hematologic …

Chimeric fusion genes are highly prevalent in childhood acute lymphoblastic leukemia (ALL)
and are mostly prenatal, early genetic events in the evolutionary trajectory of this cancer …

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with high
hyperdiploidy [51–67 chromosomes] and the t (12; 21)(p13; q22)[ETV6/RUNX1 fusion] …

The clinical heterogeneity among first relapses of childhood ETV6/RUNX1-positive acute
lymphoblastic leukemia indicates that further genetic alterations in leukemic cells might …