Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

This article purposes to provide insights to piperazine based molecular designs that will
facilitate drug discovery program in future. In our pursuit to summarize the reservoir of …

Dehydroacetic acid (DHA) is a significant heterocyclic molecule whose derivatives are
highly prevalent. Thus, a new series of heterocyclic derivatives starting from dehydroacetic …

A series of novel coumarin-piperazine derivatives (3a–3h) were synthesized and
characterized by IR, 1 H, 13 C NMR and GC–MS. All the synthesized compounds were …

This study reports the synthesis of two series of new purine bioisosteres comprising a
pyrazolo [3, 4‐d] pyrimidine scaffold linked to piperazine moiety through different amide …

Abstract A series of 3-acetyl-2-aryl-5-methylthio-2, 3-dihydro-1, 3, 4-thiadiazoles 3a–g, N-(4-
acetyl-5-aryl-4, 5-dihydro-1, 3, 4-thiadiazol-2-yl) acetamide derivatives 5a–e and spiro …

Piperazine is two nitrogen containing heterocyclic compound. The fundamental activity of
the piperazine is due to the 1, 4-position of nitrogen atoms and their substitutions. The SN 1 …

Abstract Azole antifungals are an important class of antifungal drugs due to their low cost,
ability to be administered orally, and broad-spectrum activity. However, their widespread …

Despite extensive research in the field of drug discovery and development, still there is a
need to develop novel molecular entities. Literature reveals a substantial heterocyclic …

Heterocycles are widely distributed compounds in natural products and are involved in
many biological processes. Its uses have been extended to different fields, including …