MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

The ability to respond to perturbations in endoplasmic reticulum (ER) function is a
fundamentally important property of all cells, but ER stress can also lead to apoptosis. In …

Unfolded and malfolded client proteins impose a stress on the endoplasmic reticulum (ER),
which contributes to cell death in pathophysiological conditions. The transcription factor …

p21Waf1/Cip1/Sdi1 was originally identified as an inhibitor of cyclin-dependent kinases, a
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …

Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process
called efferocytosis, are crucial determinants of atherosclerosis lesion progression and …

Diverse cellular stress responses are linked to phosphorylation of serine 51 on the alpha
subunit of translation initiation factor 2. The resultant attenuation of protein synthesis and …

Wolfram syndrome, an autosomal recessive disorder associated with diabetes mellitus and
optic atrophy, is caused by mutations in the WFS1 gene encoding an endoplasmic reticulum …

Profiles of gene transcription have begun to delineate the molecular basis of ovarian cancer,
including distinctions between carcinomas of differing histology, tumor progression and …

Cancer is a major public health issue and, despite recent advances, effective clinical
management remains elusive due to intra-tumoural heterogeneity and therapeutic …