Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
[HTML][HTML] A critical review of Astragalus polysaccharides: from therapeutic mechanisms to pharmaceutics
Y Du, H Wan, P Huang, J Yang, Y He - Biomedicine & pharmacotherapy, 2022 - Elsevier
As the important active ingredients of Astragali Radix (AR), Astragalus polysaccharides
(APs) have therapeutic potential for multiple diseases including nervous system diseases …
(APs) have therapeutic potential for multiple diseases including nervous system diseases …
[HTML][HTML] CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B
Y Dong, X Li, L Zhang, Q Zhu, C Chen, J Bao, Y Chen - BMC immunology, 2019 - Springer
Background Immune inhibitory receptors play an important role in chronic infections.
However, little is known about their role in hepatitis B virus (HBV) infection. Here, we …
However, little is known about their role in hepatitis B virus (HBV) infection. Here, we …
Response to programmed cell death-1 blockade in a murine melanoma syngeneic model requires costimulation, CD4, and CD8 T cells
B Homet Moreno, JM Zaretsky, A Garcia-Diaz… - Cancer immunology …, 2016 - AACR
The programmed cell death protein 1 (PD-1) limits effector T-cell functions in peripheral
tissues, and its inhibition leads to clinical benefit in different cancers. To better understand …
tissues, and its inhibition leads to clinical benefit in different cancers. To better understand …
Characterization of PD-L1 expression and associated T-cell infiltrates in metastatic melanoma samples from variable anatomic sites
HM Kluger, CR Zito, ML Barr, MK Baine… - Clinical Cancer …, 2015 - AACR
Abstract Purpose: Programmed death ligand-1 (PD-L1) tumor expression represents a
mechanism of immune escape for melanoma cells. Drugs blocking PD-L1 or its receptor …
mechanism of immune escape for melanoma cells. Drugs blocking PD-L1 or its receptor …
[HTML][HTML] New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity
M Pirmohamed, DA Ostrov, BK Park - Journal of Allergy and Clinical …, 2015 - Elsevier
Drug hypersensitivity reactions are an important clinical problem for both health care and
industry. Recent advances in genetics have identified a number of HLA alleles associated …
industry. Recent advances in genetics have identified a number of HLA alleles associated …
Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma
B Homet Moreno, S Mok, B Comin-Anduix… - …, 2016 - Taylor & Francis
The combination of targeted therapy with BRAF and MEK inhibitors has become the
standard of care in patients with BRAF V600E mutant melanoma, but responses are not …
standard of care in patients with BRAF V600E mutant melanoma, but responses are not …
[HTML][HTML] Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer
X Yan, SC Jiao, GQ Zhang, Y Guan, JL Wang - Cancer gene therapy, 2017 - nature.com
Dynamic interaction between tumor cells and the microenvironment is critical for
tumorigenesis, and cancer immunosurveillance plays an important role in the tumor …
tumorigenesis, and cancer immunosurveillance plays an important role in the tumor …
Mass spectrometric and functional aspects of drug–protein conjugation
The covalent binding of drugs (metabolites) to proteins to form drug–protein adducts can
have an adverse effect on the body. These adducts are thought to be responsible for …
have an adverse effect on the body. These adducts are thought to be responsible for …
HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction
K Jaruthamsophon, PJ Thomson… - Annual Review of …, 2022 - annualreviews.org
Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain
immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research …
immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research …