Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system

B Mi, Y Xiong, S Knoedler, M Alfertshofer, AC Panayi… - Bone Research, 2024 - nature.com
Ageing as a natural irreversible process inherently results in the functional deterioration of
numerous organ systems and tissues, including the skeletal and immune systems. Recent …

Role and therapeutic targeting strategies of neutrophil extracellular traps in inflammation

X Li, S Xiao, N Filipczak, SSK Yalamarty… - International Journal …, 2023 - Taylor & Francis
Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by
neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …

[HTML][HTML] Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis

TS Kim, LM Silva, VI Theofilou… - Journal of Experimental …, 2023 - rupress.org
Neutrophil infiltration is a hallmark of periodontitis, a prevalent oral inflammatory condition in
which Th17-driven mucosal inflammation leads to destruction of tooth-supporting bone …

Modifiable risk factors linked to the development of rheumatoid arthritis: evidence, immunological mechanisms and prevention

JA Maisha, HS El-Gabalawy, LJ O'Neil - Frontiers in Immunology, 2023 - frontiersin.org
Rheumatoid Arthritis (RA) is a common autoimmune disease that targets the synovial joints
leading to arthritis. Although the etiology of RA remains largely unknown, it is clear that …

Advancements in rheumatoid arthritis therapy: a journey from conventional therapy to precision medicine via nanoparticles targeting immune cells

A Laha, S Nasra, D Bhatia, A Kumar - Nanoscale, 2024 - pubs.rsc.org
Rheumatoid arthritis (RA) is a progressive autoimmune disease that mainly affects the inner
lining of the synovial joints and leads to chronic inflammation. While RA is not known as …

NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy

CS Bonilha, FP Veras, F de Queiroz Cunha - Trends in Pharmacological …, 2023 - cell.com
Neutrophil extracellular traps (NETs) are complex structures released by activated
neutrophils during inflammatory responses. Due to their unique potential for causing tissue …

[HTML][HTML] Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases

H Manoj, SM Gomes, PY Thimmappa… - Cytokine & Growth …, 2024 - Elsevier
Neutrophils, as essential component of the innate immune response, form a crucial part in
the defence mechanisms through the release of extracellular traps (NETs). These web-like …

IL33-induced neutrophil extracellular traps (NETs) mediate a positive feedback loop for synovial inflammation and NET amplification in rheumatoid arthritis

J Tang, J Xia, H Gao, R Jiang, L Xiao… - … & Molecular Medicine, 2024 - nature.com
This study investigated the mechanisms driving the induction and sustained presence of
neutrophil extracellular traps (NETs) in the synovial microenvironment of rheumatoid arthritis …

Mitochondria: A breakthrough in combating rheumatoid arthritis

S Li, C Huo, A Liu, Y Zhu - Frontiers in Medicine, 2024 - frontiersin.org
As a chronic autoimmune disease with complex aetiology, rheumatoid arthritis (RA) has
been demonstrated to be associated with mitochondrial dysfunction since mitochondrial …

Epigenetic regulation of innate immune dynamics during inflammation

BA Caldwell, L Li - Journal of leukocyte biology, 2024 - academic.oup.com
Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …