Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Importance Even though osteoarthritis is a chronic and progressive disease,
pharmacological agents are mainly studied over short-term periods, resulting in unclear …

Background: The relative efficacy of available treatments of knee osteoarthritis (OA) must be
determined for rational treatment algorithms to be formulated. Purpose: To examine the …

Few studies have assessed postoperative trends in opioid cessation and predictors of
persistent opioid use after total knee arthroplasty (TKA) and total hip arthroplasty (THA) …

Importance An American Academy of Orthopaedic Surgeons guideline recommends
tramadol for patients with knee osteoarthritis, and an American College of Rheumatology …

Introduction Regarding the efficacy of intra-articular injections of platelet-rich plasma,
hyaluronic acid and corticosteroids, current evidence is controversial. The superiority of one …

The objective of this article is to deliver a concise up-to-date review on hip osteoarthritis. We
describe the epidemiology (disease distribution), etiologies (associated risk factors) …

Objective The purpose of this paper is to revise the 2010 Dutch guideline for physical
therapy (PT) in patients with hip or knee osteoarthritis (OA), issued by the Royal Dutch …