The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …

The APOE gene is one of currently only two genes that have consistently been associated
with longevity. Apolipoprotein E (APOE) is a plasma protein which plays an important role in …

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

Background: Parkinson's disease (PD) is a prevalent neurodegenerative disease that is
pathologically described as a six-stage α-synucleinopathy. In stage 4, α-synuclein reaches …

Human apolipoprotein E (APOE), originally known for its role in lipid metabolism, is
polymorphic with three major allele forms, namely, APOEε2, APOEε3, and APOEε4, leading …

Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular
physiology. They are responsible for producing the majority of a cell's ATP, thus supplying …

APOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though
relationships between APOE-encoded apolipoprotein E and β-amyloid are increasingly well …

The etiology of common, nonfamiliar late-onset Alzheimer's disease (LOAD) is only partly
understood and seems to be extremely complex including many genetic and environmental …

BACKGROUND AND PURPOSE: Radiotherapy of thoracic and chest-wall tumours
increases the long-term risk of radiation-induced heart disease. The aim of this study was to …

This study examined the effects of apolipoprotein E4 (APOE4), the most prevalent genetic
risk factor for Alzheimer's disease (AD), on proteins involved in mitochondrial dynamics and …