Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics
Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked G–G–G–G
tetrads in monovalent cation-containing solution. The length and number of individual G …
tetrads in monovalent cation-containing solution. The length and number of individual G …
Quadruplex structures in nucleic acids
MA Keniry - Biopolymers: Original Research on Biomolecules, 2000 - Wiley Online Library
DNA oligonucleotides that have repetitive tracts of guanine bases can form G‐quadruplex
structures that display an amazing polymorphism. Structures of several new G …
structures that display an amazing polymorphism. Structures of several new G …
Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms
The technique of small-probe contact dot surfaces is described as a method for calculating
and displaying the detailed atomic contacts inside or between molecules. It allows one both …
and displaying the detailed atomic contacts inside or between molecules. It allows one both …
Biophysical and biological properties of quadruplex oligodeoxyribonucleotides
V Đapić, V Abdomerović, R Marrington… - Nucleic acids …, 2003 - academic.oup.com
Single‐stranded guanosine‐rich oligodeoxyribonucleotides (GROs) have a propensity to
form quadruplex structures that are stabilized by G‐quartets. In addition to intense …
form quadruplex structures that are stabilized by G‐quartets. In addition to intense …
1 Å crystal structures of B-DNA reveal sequence-specific binding and groove-specific bending of DNA by magnesium and calcium
TK Chiu, RE Dickerson - Journal of molecular biology, 2000 - Elsevier
The 1 Å resolution X-ray crystal structures of Mg2+ and Ca2+ salts of the B-DNA decamers
CCAACGTTGG and CCAGCGCTGG reveal sequence-specific binding of Mg2+ and Ca2+ to …
CCAACGTTGG and CCAGCGCTGG reveal sequence-specific binding of Mg2+ and Ca2+ to …
Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation
B Zamiri, M Mirceta, K Bomsztyk… - Nucleic acids …, 2015 - academic.oup.com
Unusual DNA/RNA structures of the C9orf72 repeat may participate in repeat expansions or
pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded …
pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded …
Solution structure of a Na cation stabilized DNA quadruplex containing G· G· G· G and G· C· G· C tetrads formed by GGGC repeats observed in adeno-associated viral …
We have applied NMR and molecular dynamics computations including intensity based
refinement to define the structure of the d (GGGC-T4-GGGC) dodecanucleotide in 100 mM …
refinement to define the structure of the d (GGGC-T4-GGGC) dodecanucleotide in 100 mM …
Non-G base tetrads
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the
stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures …
stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures …
V-shaped scaffold: a new architectural motif identified in an A·(G· G· G· G) pentad-containing dimeric DNA quadruplex involving stacked G (anti)· G (anti)· G (anti)· G …
N Zhang, A Gorin, A Majumdar, A Kettani… - Journal of molecular …, 2001 - Elsevier
We report the results of an NMR study of unlabeled and uniformly 13C, 15N-labeled d
(G3AG2T3G3AT) in 100 mM NaCl, conditions under which it forms a dimeric quadruplex …
(G3AG2T3G3AT) in 100 mM NaCl, conditions under which it forms a dimeric quadruplex …
A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding
The structure of the DNA duplex is arguably one of the most important biological structures
elucidated in modern history. DNA duplex structure is closely associated with essential …
elucidated in modern history. DNA duplex structure is closely associated with essential …