Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Antimalarial drug resistance and implications for the WHO global technical strategy
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of
antimalarial efficacy and transmission. Recurrent infections may arise from activation of …
antimalarial efficacy and transmission. Recurrent infections may arise from activation of …
Resolving the cause of recurrent Plasmodium vivax malaria probabilistically
Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a
major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection …
major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection …
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Malaria genomic surveillance often estimates parasite genetic relatedness using metrics
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …
Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa
ED Benavente, E Manko, J Phelan, M Campos… - Nature …, 2021 - nature.com
Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic
diversity of circulating parasite populations is not well described. Determinants of …
diversity of circulating parasite populations is not well described. Determinants of …
Molecular markers for malaria genetic epidemiology: progress and pitfalls
Over recent years, progress in molecular markers for genotyping malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …
enabled informative studies of epidemiology and transmission dynamics. Results have …
Measurably recombining malaria parasites
F Camponovo, CO Buckee, AR Taylor - Trends in parasitology, 2023 - cell.com
Genomic epidemiology has guided research and policy for various viral pathogens and
there has been a parallel effort towards using genomic epidemiology to combat diseases …
there has been a parallel effort towards using genomic epidemiology to combat diseases …
Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania
Zanzibar has made significant progress toward malaria elimination, but recent stagnation
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
Abstract The Democratic Republic of the Congo (DRC) harbors 11% of global malaria
cases, yet little is known about the spatial and genetic structure of the parasite population in …
cases, yet little is known about the spatial and genetic structure of the parasite population in …