Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables
the study of host–microbe interactions with great experimental control. This protocol …

The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

The ability to switch between different lifestyles allows bacterial pathogens to thrive in
diverse ecological niches,. However, a molecular understanding of their lifestyle changes …

With the emergence of RNA sequencing (RNA-seq) technologies, RNA-based biomolecules
hold expanded promise for their diagnostic, prognostic and therapeutic applicability in …

The last few decades have led to an explosion in our understanding of the major roles that
small regulatory RNAs (sRNAs) play in regulatory circuits and the responses to stress in …

Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence
of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of …

Bacteria respond to changes in their environment with specific transcriptional programmes,
but even within genetically identical populations these programmes are not homogenously …