Neutron scattering in the biological sciences: progress and prospects
The scattering of neutrons can be used to provide information on the structure and dynamics
of biological systems on multiple length and time scales. Pursuant to a National Science …
of biological systems on multiple length and time scales. Pursuant to a National Science …
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography
DW Kneller, G Phillips, KL Weiss, S Pant… - Journal of Biological …, 2020 - ASBMB
The main protease (3CL M pro) from SARS–CoV-2, the etiological agent of COVID-19, is an
essential enzyme for viral replication. 3CL M pro possesses an unusual catalytic dyad …
essential enzyme for viral replication. 3CL M pro possesses an unusual catalytic dyad …
New strategies for protein crystal growth
JM Wiencek - Annual review of biomedical engineering, 1999 - annualreviews.org
▪ Abstract Protein crystallization is the most difficult and time-consuming step in the
determination of a protein's atomic structure. As X-ray diffraction becomes a commonly …
determination of a protein's atomic structure. As X-ray diffraction becomes a commonly …
Magnetic structure of the quasi-two-dimensional antiferromagnet
AR Wildes, V Simonet, E Ressouche, GJ Mcintyre… - Physical Review B, 2015 - APS
The magnetic structure of the quasi-two-dimensional antiferromagnet NiPS 3 has been
determined by magnetometry and a variety of neutron diffraction techniques. The …
determined by magnetometry and a variety of neutron diffraction techniques. The …
Structure of a protein photocycle intermediate by millisecond time-resolved crystallography
UK Genick, GEO Borgstahl, K Ng, Z Ren, C Pradervand… - Science, 1997 - science.org
The blue-light photoreceptor photoactive yellow protein (PYP) undergoes a self-contained
light cycle. The atomic structure of the bleached signaling intermediate in the light cycle of …
light cycle. The atomic structure of the bleached signaling intermediate in the light cycle of …
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis
I Schlichting, SC Almo, G Rapp, K Wilson, K Petratos… - Nature, 1990 - nature.com
Abstract Crystals of Ha-Ras p21 with caged GTP at the active site have been used to
investigate the conformational changes of p21 on GTP hydrolysis. The structure of the short …
investigate the conformational changes of p21 on GTP hydrolysis. The structure of the short …
Pink-beam serial crystallography
Serial X-ray crystallography allows macromolecular structure determination at both X-ray
free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for …
free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for …
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature
GJ Correy, DW Kneller, G Phillips, S Pant, S Russi… - Science …, 2022 - science.org
The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(Mac1) removes adenosine diphosphate (ADP) ribosylation …
coronavirus 2 (SARS-CoV-2)(Mac1) removes adenosine diphosphate (ADP) ribosylation …
Direct observation of protonation state modulation in SARS-CoV-2 main protease upon inhibitor binding with neutron crystallography
DW Kneller, G Phillips, KL Weiss, Q Zhang… - Journal of medicinal …, 2021 - ACS Publications
The main protease (3CL Mpro) from severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the virus that causes COVID-19, is an essential enzyme for viral replication …
(SARS-CoV-2), the virus that causes COVID-19, is an essential enzyme for viral replication …
Structure of the Regulatory Complex of Escherichia coli IIIGlc with Glycerol Kinase
JH Hurley, HR H. Rick, D Worthylake, ND Meadow… - Science, 1993 - science.org
The phosphocarrier protein IIIGlc is an integral component of the bacterial
phosphotransferase (PTS) system. Unphosphorylated IIIGlc inhibits non-PTS carbohydrate …
phosphotransferase (PTS) system. Unphosphorylated IIIGlc inhibits non-PTS carbohydrate …