Advanced-stage pancreatic cancer: therapy options

J Werner, SE Combs, C Springfeld, W Hartwig… - Nature reviews Clinical …, 2013 - nature.com
Pancreatic ductal adenocarcinoma is one of the most aggressive cancers, and surgical
resection is a requirement for a potential cure. However, the majority of patients are …

Stereotactic body radiation therapy for locally advanced pancreatic cancer: a systematic review and pooled analysis of 19 trials

F Petrelli, T Comito, A Ghidini, V Torri… - International Journal of …, 2017 - Elsevier
Purpose Although surgery is the standard of care for resectable pancreatic cancer (PC),
standard-dose chemoradiation therapy and chemotherapy alone are suitable for patients …

Using adaptive magnetic resonance image‐guided radiation therapy for treatment of inoperable pancreatic cancer

S Rudra, N Jiang, SA Rosenberg, JR Olsen… - Cancer …, 2019 - Wiley Online Library
Background Adaptive magnetic resonance imaging‐guided radiation therapy (MRgRT) can
escalate dose to tumors while minimizing dose to normal tissue. We evaluated outcomes of …

Locally advanced, unresectable pancreatic cancer: American Society of Clinical Oncology clinical practice guideline

EP Balaban, PB Mangu, AA Khorana… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To provide evidence-based recommendations to oncologists and others for
treatment of patients with locally advanced, unresectable pancreatic cancer. Methods …

Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated

MD Chuong, GM Springett, JM Freilich, CK Park… - International Journal of …, 2013 - Elsevier
PURPOSE: Stereotactic body radiation therapy (SBRT) provides high rates of local control
(LC) and margin-negative (R0) resections for locally advanced pancreatic cancer (LAPC) …

Long-term outcomes of induction chemotherapy and neoadjuvant stereotactic body radiotherapy for borderline resectable and locally advanced pancreatic …

EA Mellon, SE Hoffe, GM Springett, JM Frakes… - Acta …, 2015 - Taylor & Francis
Purpose. Limited data are available to guide neoadjuvant treatment of borderline resectable
(BRPC) and locally advanced (LAPC) pancreatic cancer. Material and methods. We updated …

[HTML][HTML] Ablative five-fraction stereotactic body radiation therapy for inoperable pancreatic cancer using online MR-guided adaptation

C Hassanzadeh, S Rudra, A Bommireddy… - Advances in radiation …, 2021 - Elsevier
Purpose Patients with inoperable pancreatic adenocarcinoma have limited options, with
traditional chemoradiation providing modest clinical benefit and an otherwise poor …

Conventionally fractionated radiation therapy versus stereotactic body radiation therapy for locally advanced pancreatic cancer (CRiSP): An international systematic …

LT Tchelebi, EJ Lehrer, DM Trifiletti, NK Sharma… - Cancer, 2020 - Wiley Online Library
Background The goal of this study was to characterize the efficacy and safety of stereotactic
body radiation therapy (SBRT) versus conventionally fractionated radiation therapy with …

Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer

SJE Rombouts, JA Vogel… - Journal of British …, 2015 - academic.oup.com
Background Locally advanced pancreatic cancer (LAPC) is associated with a very poor
prognosis. Current palliative (radio) chemotherapy provides only a marginal survival benefit …

Simulated computed tomography-guided stereotactic adaptive radiotherapy (CT-STAR) for the treatment of locally advanced pancreatic cancer

JP Schiff, AT Price, HB Stowe, E Laugeman… - Radiotherapy and …, 2022 - Elsevier
Background and purpose We conducted a prospective, in silico imaging clinical trial to
evaluate the feasibility and potential dosimetric benefits of computed tomography-guided …