The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Startle syndromes consist of three heterogeneous groups of disorders with abnormal
responses to startling events. The first is hyperekplexia, which can be split up into the" …

Cannabinoids enhance the function of glycine receptors (GlyRs). However, little is known
about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using …

Alterations in synaptic transmission within the spinal cord dorsal horn play a key role in the
development of pathological pain. While N-methyl-D-aspartate (NMDA) receptors and …

Since 1996, nearly 100 genes have been studied for their effects related to ethanol in mice
using genetic modifications including gene deletion, gene overexpression, gene knock‐in …

Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion‐selective transmitter‐
gated ion channels of the cys‐loop superfamily, which includes among others also the …

The neurotransmitter glycine is an agonist at the strychnine‐sensitive glycine receptors. In
addition, it has recently been discovered to act at two new receptors, the excitatory glycine …

Diminished inhibitory neurotransmission in the superficial dorsal horn of the spinal cord is
thought to contribute to chronic pain. In inflammatory pain, reductions in synaptic inhibition …

Although postsynaptic glycine receptors (GlyRs) as αβ heteromers attract considerable
research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in …

GABAA receptors consisting of ρ1, ρ2, or ρ3 subunits in homo-or hetero-pentamers have
been studied mainly in retina but are detected in many brain regions. Receptors formed from …