The HIV-1 envelope glycoprotein (Env) trimer, composed of gp120 and gp41 subunits,
mediates viral entry into cells. Recombinant Env trimers have been studied structurally, but …

The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of
conformational transitions, with allosteric elements in each protomer orchestrating host …

The HIV-1 envelope glycoprotein (Env) mediates host cell fusion and is the primary target for
HIV-1 vaccine design. The Env undergoes a series of functionally important conformational …

The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series
of receptor-induced structural changes. Although remarkable progress has been made in …

Binding to the receptor, CD4, drives the pretriggered,“closed”(state-1) conformation of the
human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more …

Binding to the receptor, CD4, drives the pretriggered,“closed”(State-1) conformation of the
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ([gp120/gp41] 3) …

Antibody variable domains contain “complementarity-determining regions”(CDRs), the loops
that form the antigen binding site. CDRs1-3 are recognized as the canonical CDRs …

The membrane proximal external region (MPER) of HIV-1 envelope glycoprotein (gp) 41 is
an attractive vaccine target for elicitation of broadly neutralizing antibodies (bNAbs) by …

Binding to the receptor CD4 triggers entry-related conformational changes in the human
immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer,(gp120/gp41) 3 …

HIV-1 strains are categorized into one of three neutralization tiers based on the relative ease
by which they are neutralized by plasma from HIV-1–infected donors not on antiretroviral …