Rac1: A regulator of cell migration and a potential target for cancer therapy
N Ma, E Xu, Q Luo, G Song - Molecules, 2023 - mdpi.com
Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …
[HTML][HTML] TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease
Y Li, H Xu, H Wang, K Yang, J Luan, S Wang - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …
loss of cognitive ability and memory. However, there is no specific treatment to …
The role of osteopontin in microglia biology: current concepts and future perspectives
The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …
Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment
MA Hill, SC Gammie - Scientific reports, 2022 - nature.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects multiple
brain regions and is difficult to treat. In this study we used 22 AD large-scale gene …
brain regions and is difficult to treat. In this study we used 22 AD large-scale gene …
Rho signaling in synaptic plasticity, memory, and brain disorders
Memory impairments are associated with many brain disorders such as autism, Alzheimer's
disease, and depression. Forming memories involves modifications of synaptic transmission …
disease, and depression. Forming memories involves modifications of synaptic transmission …
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions
M Takalo, R Wittrahm, B Wefers, S Parhizkar… - Molecular …, 2020 - Springer
Background Microglia-specific genetic variants are enriched in several neurodegenerative
diseases, including Alzheimer's disease (AD), implicating a central role for alterations of the …
diseases, including Alzheimer's disease (AD), implicating a central role for alterations of the …
Progress in the therapeutic inhibition of Cdc42 signalling
Cdc42 is a member of the Rho family of small GTPases and a key regulator of the actin
cytoskeleton, controlling cell motility, polarity and cell cycle progression. It signals …
cytoskeleton, controlling cell motility, polarity and cell cycle progression. It signals …
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model
Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
[HTML][HTML] Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance
Microglia, the largest population of brain immune cells, continuously interact with synapses
to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting …
to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting …
Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease
Dysregulation of gene expression in Alzheimer's disease (AD) remains elusive, especially at
the cell type level. Gene regulatory network, a key molecular mechanism linking …
the cell type level. Gene regulatory network, a key molecular mechanism linking …