Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Mechanisms of viral mutation

R Sanjuán, P Domingo-Calap - Cellular and molecular life sciences, 2016 - Springer
The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …

Antiviral drug resistance as an adaptive process

KK Irwin, N Renzette, TF Kowalik, JD Jensen - Virus evolution, 2016 - academic.oup.com
Antiviral drug resistance is a matter of great clinical importance that, historically, has been
investigated mostly from a virological perspective. Although the proximate mechanisms of …

Who is the patient at risk of CMV recurrence: a review of the current scientific evidence with a focus on hematopoietic cell transplantation

J Styczynski - Infectious diseases and therapy, 2018 - Springer
Cytomegalovirus (CMV) is an agent of global infection, and its acquisition in a population is
characterized by an age-dependent rise in seropositivity. After primary infection, CMV …

Genomic and geographical structure of human cytomegalovirus

OJ Charles, C Venturini, S Gantt… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (CMV) has infected humans since the origin of our species and
currently infects most of the world's population. Variability between CMV genomes is the …

The Pacific oyster mortality syndrome, a polymicrobial and multifactorial disease: state of knowledge and future directions

B Petton, D Destoumieux-Garzón, F Pernet… - Frontiers in …, 2021 - frontiersin.org
The Pacific oyster (Crassostreae gigas) has been introduced from Asia to numerous
countries around the world during the 20th century. C. gigas is the main oyster species …

Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus

A Bootz, A Karbach, J Spindler, B Kropff… - PLoS …, 2017 - journals.plos.org
Human cytomegalovirus (HCMV) is an important, ubiquitous pathogen that causes severe
clinical disease in immunocompromised individuals, such as organ transplant recipients and …

New therapies for human cytomegalovirus infections

WJ Britt, MN Prichard - Antiviral research, 2018 - Elsevier
The recent approval of letermovir marks a new era of therapy for human cytomegalovirus
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …

Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: Predictions for medical translation that survived the “test of time”

MJ Reddehase, NAW Lemmermann - Viruses, 2018 - mdpi.com
Human Cytomegalovirus (hCMV), which is the prototype member of the β-subfamily of the
herpesvirus family, is a pathogen of high clinical relevance in recipients of hematopoietic …

An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants

MZI Khan, A Nazli, H Al-Furas, MI Asad, I Ajmal… - Frontiers in …, 2022 - frontiersin.org
Viruses are submicroscopic, obligate intracellular parasites that carry either DNA or RNA as
their genome, protected by a capsid. Viruses are genetic entities that propagate by using the …