Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Creatine is a nitrogen-containing organic acid naturally existing in mammals. It can be
converted into phosphocreatine to provide energy for muscle and nerve tissues. Creatine …

PARP inhibitors (PARPi) prevent cancer cell growth by inducing synthetic lethality with DNA
repair defects (eg, in BRCA1/2 mutant cells). We have identified an alternative pathway for …

A key cellular process associated with the invasive or metastatic program in many cancers is
the transformation of epithelial cells toward a mesenchymal state, a process called epithelial …

Expression of the MECOM (also known as EVI1) proto-oncogene is deregulated by
chromosomal translocations in some cases of acute myeloid leukemia (AML) and is …

Epigenetic changes are considered to be a frequent event during tumour development.
Hypermethylation of promoter CpG islands represents an alternative mechanism to …

The nucleolus has been known for a long time to fulfill crucial functions in ribosome
biogenesis, of which cancer cells can become addicted to in order to produce sufficient …

Guanine quadruplexes (G4s) are an important structure of nucleic acids (DNA and RNA)
with roles in several cellular processes. RNA G4s require specialized unwinding enzymes …

Keratins (KRTs), the intermediate filament-forming proteins of epithelial cells, are extensively
used as diagnostic biomarkers in cancers and associated with tumorigenesis and …

Clear cell sarcoma of kidney (CCSK) is classified as a tumour of unfavourable histology by
the National Wilms' Tumor Study Group. It has worse clinical outcomes than Wilms' tumour …