Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been
collaborating in a major project called “SYNAPSE”(Synchrotrons for Neuroscience: an Asia …

The stable transgenesis of genes encoding functional or spatially localized proteins, fused to
fluorescent proteins such as green fluorescent protein (GFP) or red fluorescent protein …

During embryogenesis, cells repeatedly divide and dynamically change their positions in
three-dimensional (3D) space. A robust and accurate algorithm to acquire the 3D positions …

Stereologic cell counting has had a major impact on the field of neuroscience. A major
bottleneck in stereologic cell counting is that the user must manually decide whether or not …

Microscopy imaging, including fluorescence micro scopy and electron microscopy, has
taken a prominent role in life science research and medicine due to its ability to investigate …

To measure the activity of neurons using whole-brain activity imaging, precise detection of
each neuron or its nucleus is required. In the head region of the nematode C. elegans, the …

Motivation: Rapid advances in live-cell imaging analysis and mathematical modeling have
produced a large amount of quantitative data on spatiotemporal dynamics of biological …

Drawing the map of neuronal circuits at microscopic resolution is important to explain how
brain works. Recent progresses in fluorescence labeling and imaging techniques have …

Automated microscope systems are increasingly used to collect large-scale 3D image
volumes of biological tissues. Since cell boundaries are seldom delineated in these images …

Individual cells play essential roles in the biological processes of the brain. The number of
neurons changes during both normal development and disease progression. High …