Highlights•The intrinsic dynamics, encoded in proteins' sequences and structures, are
utilized by stimuli to trigger allosteric and functional actions.•The modes of allosteric actions …

Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and
Lindenmann in 1957, but they are now known to also modulate innate and adaptive …

Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality
in infants< 2 years-old. Here we describe that high-fiber diet protects mice from RSV …

Novel biophysical tools allow the structural dynamics of proteins and the regulation of such
dynamics by binding partners to be explored in unprecedented detail. Although this has …

Type I and type III interferons (IFNs) are major components in activating the innate immune
response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and …

Abstract The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the
haemopoietic, vascular and immune systems and is overexpressed in acute and chronic …

Cytokines comprise a large family of secreted ligands that are critical for the regulation of
immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the …

The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind
their cognate receptors, IFNα/β receptor (IFNAR) 1 and IFNAR2. These signals contribute to …

Most biological processes involve formation of transient complexes where binding of a
ligand allosterically modulates function. The ccd toxin-antitoxin system is involved in plasmid …

We hereby describe the process of design and selection of nonantibody protein binders
mimicking cytokine signaling. We chose to mimic signaling of IFN‐λ1, type 3 interferon (also …