Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra,
resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial …

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

Resveratrol (RES), a natural polyphenolic compound found in red wine and grape skins, has
attracted significant attention due to its cardioprotective properties. DJ-1, a multifunctional …

DJ-1 is a highly conserved multifunctional protein linked to both neurodegeneration and
neoplasia. Among its various activities is an antioxidant property leading to cytoprotection …

Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …

No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating
neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease …

Glutamate represents a key excitatory neurotransmitter in the central nervous system, and
also modulates the function and viability of endocrine cells in pancreatic islets. In insulin …

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival and regeneration-
promoting factor for dopaminergic neurons in cell and animal models of Parkinson disease …