PPARγ and Wnt signaling in adipogenic and osteogenic differentiation of mesenchymal stem cells

Z Yuan, Q Li, S Luo, Z Liu, D Luo… - Current stem cell …, 2016 - ingentaconnect.com
Mesenchymal stem cells (MSCs) arise from a variety of tissues, including bone marrow and
adipose tissue and, accordingly, have the potential to differentiate into multiple cell types …

The role of the Wnt canonical signaling in neurodegenerative diseases

R Libro, P Bramanti, E Mazzon - Life sciences, 2016 - Elsevier
The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes
throughout development and adult life. Growing evidences have suggested that …

Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia

T Guo, M Chen, J Liu, Z Wei, J Yuan, W Wu… - Journal of translational …, 2023 - Springer
Objectives Available literature documents that ischemic stroke can disrupt the morphology
and function of mitochondria and that the latter in other disease models can be preserved by …

Regulation of ABC transporters at the blood–brain barrier

DS Miller - Clinical Pharmacology & Therapeutics, 2015 - Wiley Online Library
ATP binding cassette (ABC) transporters at the blood–brain barrier function as ATP‐driven
xenobiotic efflux pumps and limit delivery of small molecule drugs to the brain. Here I review …

Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease

T Zhou, G Zu, X Zhang, X Wang, S Li, X Gong… - …, 2016 - Elsevier
Abstract Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has
low toxicity and has been shown to have neuroprotective effects. The objectives of the …

Role of Wnt signaling in central nervous system injury

C Lambert, P Cisternas, NC Inestrosa - Molecular Neurobiology, 2016 - Springer
The central nervous system (CNS) is highly sensitive to external mechanical damage,
presenting a limited capacity for regeneration explained in part by its inability to restore …

Wnts in action: from synapse formation to synaptic maintenance

EM Dickins, PC Salinas - Frontiers in cellular neuroscience, 2013 - frontiersin.org
A proper balance between synapse assembly and disassembly is crucial for the formation of
functional neuronal circuits and synaptic plasticity in the adult brain. During development …

Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators

E Acaz-Fonseca, R Sanchez-Gonzalez… - Molecular and cellular …, 2014 - Elsevier
Neuroprotective actions of 17β-estradiol (estradiol) are in part mediated by direct actions on
neurons. Astrocytes, which play an essential role in the maintenance of the homeostasis of …

Male and female mice exhibit divergent responses of the cortical vasculature to traumatic brain injury

A Jullienne, A Salehi, B Affeldt, M Baghchechi… - Journal of …, 2018 - liebertpub.com
We previously reported that traumatic brain injuries (TBI) alter the cerebrovasculature near
the injury site in rats, followed by revascularization over a 2-week period. Here, we tested …

The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target?

W Wan, S Xia, B Kalionis, L Liu… - BioMed research …, 2014 - Wiley Online Library
Accumulating evidence supports a key role for Wnt signaling in the development of the
central nervous system (CNS) during embryonic development and in the regulation of the …