Historically, nutrition principles and recommendations for diabetes and related
complications have been based on scientific evidence and diabetes knowledge when …

Diabetes mellitus is a metabolic disorder in the endocrine system. This dreadful disease is
found in all parts of the world and becoming a serious threat of mankind health. There are …

Brain ischemia initiates a complex cascade of metabolic events, several of which involve the
generation of nitrogen and oxygen free radicals. These free radicals and related reactive …

Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given
at high doses for a variety of therapeutic applications. It is currently in trial as a potential …

Background The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major
autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum …

We propose that the presumed multiple effects of Nampt/PBEF/visfatin may be entirely
explained by its role as an intra and extracellular NAD biosynthetic enzyme. We also …

Experimental studies indicate that overactivation of the DNA repair protein poly (ADP-ribose)
polymerase (PARP) in response to oxidative damage to DNA can cause cell death due to …

Although many risk factors can trigger the development of insulin‐dependent diabetes
(IDDM), it is likely that reactive oxygen species (ROS) play a central role in β‐cell death and …

Aims/hypothesis. Induction of tolerance to insulin is achievable in animal models of Type I
(insulin-dependent) Diabetes mellitus by oral treatment with this hormone, which can lead to …

Diabetes mellitus is associated with an increased production of reactive oxygen species and
a reduction in antioxidant defenses. This leads to oxidative stress, which is partly …