Emerging therapeutic potential of cannabidiol (CBD) in neurological disorders: a comprehensive review

K Singh, B Bhushan, DK Chanchal… - Behavioural …, 2023 - Wiley Online Library
Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its
potential therapeutic applications. This thorough analysis explores the increasing …

A retrospective review of marine algae and the strategies employed for prospective diabetes management

A Animish, MA Jayasri - Algal Research, 2023 - Elsevier
The prevalence of diabetes increases with each passing day, making it essential to develop
novel, cost-effective, and side-effect-free alternatives for managing and controlling the …

A comprehensive review of the pharmacological importance of dietary flavonoids as hepatoprotective agents

Gajender, A Mazumder, A Sharma… - Evidence‐Based …, 2023 - Wiley Online Library
The liver is a crucial organ that is involved in various kinds of metabolic activity and a very
stable accessory gland for the digestive system. Long‐term or persistent inflammation and …

Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression, intracellular lipid accumulation and improves insulin secretory defects in pancreatic beta cells

S Nag, S Mandal, O Mukherjee, T Majumdar… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Dipeptidyl peptidase-4 (DPP-4), a ubiquitous proteolytic enzyme, inhibits insulin
secretion from pancreatic beta cells by inactivating circulating incretin hormones GLP-1 and …

Exploring Promising Therapies for Non-Alcoholic Fatty Liver Disease: A ClinicalTrials. gov Analysis

OE Hegazi, SO Alalalmeh, M Shahwan… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Background Non-alcoholic fatty liver disease (NAFLD) is a common disease and has been
increasing in recent years. To date, no FDA-approved drug specifically targets NAFLD …

In vivo inhibition of dipeptidyl peptidase 4 allows measurement of GLP-1 secretion in mice

MM Smits, KD Galsgaard, SL Jepsen… - Diabetes, 2024 - Am Diabetes Assoc
Dipeptidyl peptidase 4 (DPP-4) and neprilysin (NEP) rapidly degrade glucagon-like peptide
1 (GLP-1) in mice. Commercially available sandwich ELISA kits may not accurately detect …

Association of dipeptidyl peptidase-4 inhibitors use with reduced risk of hepatocellular carcinoma in type 2 diabetes patients with chronic HBV infection

TI Chen, FJ Lee, WL Hsu, YC Chen, M Chen - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) was the sixth most common cancer and
the third leading cause of cancer death worldwide in 2020. Several studies have …

[HTML][HTML] Therapeutic Peptides in the Treatment of Digestive Inflammation: Current Advances and Future Prospects

L He, A Li, P Yu, S Qin, HY Tan, D Zou, H Wu… - Pharmacological …, 2024 - Elsevier
Digestive inflammation is a widespread global issue that significantly impacts quality of life.
Recent advances have highlighted the unique potential of therapeutic peptides for treating …

Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles

EA Elmorsy, ME Youssef, MR Abdel-Hamed… - Frontiers in …, 2024 - frontiersin.org
Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation
and intestinal fibrosis. Despite the availability of various treatments, many patients fail to …

Mitochondrial signaling pathways and their role in cancer drug resistance

A Sharma, T Virmani, G Kumar, A Sharma, R Virmani… - Cellular …, 2024 - Elsevier
Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …