The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

A major metabolic aberration associated with cancer is a change in glucose metabolism.
Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the …

Fructose consumption is linked to the rising incidence of obesity and cancer, which are two
of the leading causes of morbidity and mortality globally,. Dietary fructose metabolism …

Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite
for macrophage phenotype transition. Pyruvate kinase M2 (PKM2) is an essential molecular …

Serine and glycine are biosynthetically linked, and together provide the essential precursors
for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth …

Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of
the “hallmarks of cancer”. This metabolic phenotype is characterized by preferential …

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and
ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There …

Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the
PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes …

Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer
cell survival. We show that, in human lung cancer cells, acute increases in intracellular …