Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

Anti-Müllerian hormone (AMH), a member of the transforming growth factor-β family, is an
important factor of male sex differentiation. It is produced by Sertoli cells from the time of fetal …

(AMH/MIS) was first suggested by Jost, more than Four decades before this gonadal
glycoprotein was purified and its gene and promoter sequenced. In mammals, AMH …

Mutations were introduced into conserved steroidogenic factor 1 (SF1)–and SOX9-binding
sites within the endogenous mouse Müllerian inhibiting substance (Mis) promoter. Male …

Abstract Dr. Alfred Jost pioneered the field of reproductive endocrinology with his seminal
observation that two hormones produced by the testes are required for the male embryo to …

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially
designated NR5A1) has emerged as an essential regulator of endocrine development and …

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP, encoded by
the NR5A1 gene) is an essential regulator of endocrine development and function. Initially …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …