Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …

Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-
36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor …

Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular
psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 …

The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-
36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory …

Interleukin (IL)-37 and IL-33 are among the latest cytokines identified, playing a role in
several inflammatory conditions, spanning from systemic conditions to tumors to localized …

IL-37 was discovered as an anti-inflammatory and immunosuppressive cytokine of the IL-1
family. Significant advancements in the understanding of signaling pathways associated …

Interleukin (IL)-33 and IL-37 have been identified as novel cytokines involved in various
inflammatory diseases. However, their specific roles remain largely unknown. Recent …

IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific
cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP …

IL-33 is a relatively new member of the IL-1 cytokine family, which plays a unique role in
autoimmune diseases, particularly some oral diseases dominated by immune factors. The IL …

A member of the interleukin (IL)-1 superfamily was IL-36, which contained IL-36α, IL-36β, IL-
36γ, and IL-36Ra. Heterotrimer complexes, consisting of heterodimeric receptor complexes …