IFITM protein regulation and functions: Far beyond the fight against viruses

N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …

Infections, inflammation, and psychiatric illness: review of postmortem evidence

MJ Webster - Microorganisms and Mental Health, 2022 - Springer
While there is an abundance of epidemiological evidence implicating infectious agents in
the etiology of severe mental illnesses, postmortem studies have not yet detected an …

[HTML][HTML] Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144/rs12252 haplotypes and COVID-19

E Cuesta-Llavona, GM Albaiceta… - Current Research in …, 2021 - Elsevier
The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the
defence against viral infection. IFITM3 gene variants have been linked to differences in …

Differential transcriptomics analysis of IPEC-J2 cells single or coinfected with porcine epidemic diarrhea virus and transmissible gastroenteritis virus

L Song, J Chen, P Hao, Y Jiang, W Xu, L Li… - Frontiers in …, 2022 - frontiersin.org
Porcine epidemic diarrhea (PED) and transmissible gastroenteritis (TGE) caused by porcine
epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are two …

Antiviral role of IFITM3 in prototype foamy virus infection

Z Wang, X Tuo, J Zhang, K Chai, J Tan, W Qiao - Virology journal, 2022 - Springer
Abstract Background Foamy viruses (FVs) are retroviruses with unique replication strategies
that cause lifelong latent infections in their hosts. FVs can also produce foam-like cytopathic …

[HTML][HTML] Transmembrane domain of IFITM3 is responsible for its interaction with influenza virus HA2 subunit

W Xu, Y Wang, L Li, X Qu, Q Liu, T Li, S Wu, M Liao… - Virologica Sinica, 2022 - Elsevier
Interferon-inducible transmembrane protein 3 (IFITM3) inhibits influenza virus infection by
blocking viral membrane fusion, but the exact mechanism remains elusive. Here, we …

IFITM3 promotes NiV envelope protein-mediated entry into MDCK cells and interacts with the fusion subunit of the F protein

W Xu, SW Du, LT Li, XS Shi, JM Wang, TY Li… - … International Journal of …, 2022 - Elsevier
IFITM proteins are a host restriction factor with broad-spectrum antiviral activity, but the role
in the paramyxovirus entry remains unclear. Nipah virus (NiV) is a zoonotic virus of the …

Identification of a novel interferon lambda splice variant in chickens

J Chen, P Li, W Zou, Y Jiang, L Li, P Hao… - Journal of …, 2023 - Am Soc Microbiol
Type III interferons (IFNLs) have critical roles in the host's innate immune system, also
serving as the first line against pathogenic infections of mucosal surfaces. In mammals …

Unveiling the genetic symphony: Diversity and expression of chicken IFITM genes in Aseel and Kadaknath breeds

M Muthusamy, M Nagarajan, S Karuppusamy… - Heliyon, 2024 - cell.com
In this investigation, single nucleotide variants (SNVs) within the chicken interferon-inducible
transmembrane protein (chIFITM) genes were explored in Aseel and Kadaknath breeds …

IFITM3 rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis

K Yu, J Wang, H Li, W Wang - Experimental and …, 2023 - spandidos-publications.com
Interferon‑induced transmembrane protein 3 (IFITM3) serves a critical role in the immune
defense against viral infection, including that of severe acute respiratory syndrome …