Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are
changes in lipid metabolism that support their survival and function. Fatty acid binding …

Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors
worldwide. HCC is a complex process that is associated with several etiological factors …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

The transforming growth factor-β (TGF-β) signaling plays a critical role in the development
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …

Transforming growth factor β (TGF-β) is an important signaling molecule which is expressed
in three different isoforms in mammals (ie TGF-β1,-β2, and-β3). The interaction between TGF …

Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …

Hepatocellular carcinoma is today the sixth leading cause of cancer-related death
worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the …