Myelodysplastic syndromes: 2023 update on diagnosis, risk‐stratification, and management

G Garcia‐Manero - American journal of hematology, 2023 - Wiley Online Library
Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …

Current challenges and unmet medical needs in myelodysplastic syndromes

U Platzbecker, AS Kubasch, C Homer-Bouthiette… - Leukemia, 2021 - nature.com
Myelodysplastic syndromes (MDS) represent a heterogeneous group of myeloid neoplasms
that are characterized by ineffective hematopoiesis, variable cytopenias, and a risk of …

Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management

G Garcia‐Manero, KS Chien… - American journal of …, 2020 - Wiley Online Library
Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …

Current and emerging strategies for management of myelodysplastic syndromes

C Saygin, HE Carraway - Blood reviews, 2021 - Elsevier
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with
varying degrees of dysplasia and peripheral cytopenias. MDS are driven by structural …

SOHO State of the Art & Next Questions: Myelodysplastic Syndromes: A New Decade

VO Volpe, G Garcia-Manero, RS Komrokji - Clinical Lymphoma Myeloma …, 2022 - Elsevier
Myelodysplastic syndromes (MDS) are a group of heterogeneous clonal hematopoietic stem
cell disorders. The 2020 Surveillance, Epidemiology, and End Results data demonstrates …

Molecular Drivers of Myelodysplastic Neoplasms (MDS)—Classification and Prognostic Relevance

FW Hoff, YF Madanat - Cells, 2023 - mdpi.com
Myelodysplastic neoplasms (MDS) form a broad spectrum of clonal myeloid malignancies
arising from hematopoietic stem cells that are characterized by progressive and refractory …

Current status of phase 3 clinical trials in high-risk myelodysplastic syndromes: pitfalls and recommendations

G Garcia-Manero - The Lancet Haematology, 2023 - thelancet.com
Single-agent hypomethylating agents remain the cornerstone of treatment for patients with
high-risk myelodysplastic syndromes. Although these agents have clinical activity and can …

Prognostication in myelodysplastic syndromes (neoplasms): molecular risk stratification finally coming of age

Z Xie, EC Chen, M Stahl, AM Zeidan - Blood Reviews, 2023 - Elsevier
Accurate risk prognostication is central to the management of myelodysplastic syndromes,
given the widely heterogeneous clinical outcomes of these bone marrow failure disorders …

Lower risk but high risk

AE DeZern - Hematology, 2021 - ashpublications.org
Risk stratification is crucial to the appropriate management of most cancers, but in patients
with myelodysplastic syndromes (MDS), for whom expected survival can vary from a few …

The absolute monocyte count at diagnosis affects prognosis in myelodysplastic syndromes independently of the IPSS-R risk score

T Silzle, S Blum, A Kasprzak, K Nachtkamp, M Rudelius… - Cancers, 2023 - mdpi.com
Simple Summary The revised international prognostic scoring system (IPSS-R) represents
the standard tool for prognostication in myelodysplastic syndromes (MDSs). It considers the …