The biology of Acanthamoeba keratitis

JY Niederkorn - Experimental eye research, 2021 - Elsevier
Acanthamoeba keratitis (AK) is a rare protozoal infection of the cornea. At least eight species
of Acanthamoeba are known to cause this sight-threatening disease of the ocular surface …

Immunopathogenicity of Acanthamoeba spp. in the Brain and Lungs

K Kot, N Łanocha-Arendarczyk… - International Journal of …, 2021 - mdpi.com
Free-living amoebas, including Acanthamoeba spp., are widely distributed in soil, water, and
air. They are capable of causing granulomatous amebic encephalitis, Acanthamoeba …

[HTML][HTML] Focus: infectious diseases: pathobiology and immunobiology of Acanthamoeba keratitis: insights from animal models

S Neelam, JY Niederkorn - The Yale journal of biology and …, 2017 - ncbi.nlm.nih.gov
Acanthamoeba keratitis (AK) is a rare but sight-threatening disease caused by pathogenic
species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low …

Azole antifungal agents to treat the human pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through inhibition of sterol 14α-demethylase (CYP51)

DC Lamb, AGS Warrilow, NJ Rolley… - Antimicrobial Agents …, 2015 - Am Soc Microbiol
In this study, we investigate the amebicidal activities of the pharmaceutical triazole CYP51
inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and …

Three encephalitis-causing amoebae and their distinct interactions with the host

MJ Sarink, NL van der Meijs, K Denzer… - Trends in …, 2022 - cell.com
Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba spp. can cause devastating
brain infections in humans which almost always result in death. The symptoms of the three …

In vivo CNS infection model of Acanthamoeba genotype T4: the early stages of infection lack presence of host inflammatory response and are a slow and contact …

M Omaña-Molina, D Hernandez-Martinez… - Parasitology …, 2017 - Springer
This study was developed in order to describe the early morphological events observed
during the invasion of two pathogenic strains of Acanthamoeba (genotype T4); A. castellanii …

Major Histocompatibility Complex Class II Dextramers: New Tools for the Detection of antigen‐Specific, CD 4 T Cells in Basic and Clinical Research

C Massilamany, B Krishnan… - Scandinavian journal of …, 2015 - Wiley Online Library
The advent of major histocompatibility complex (MHC) tetramer technology has been a
major contribution to T cell immunology, because tetramer reagents permit detection of …

Experimental Granulomatous Amebic Encephalitis Caused by Acanthamoeba castellanii

SL Borges, ES de Macedo, FAV da Silva… - Tropical Medicine and …, 2024 - mdpi.com
Acanthamoeba genus can affect humans with diseases such as granulomatous amebic
encephalitis (GAE), a highly lethal neuroinfection. Several aspects of the disease still need …

Experimental infection of T4 Acanthamoeba genotype determines the pathogenic potential

DSMM Alves, AS Moraes, LM Alves… - Parasitology …, 2016 - Springer
T4 is the Acanthamoeba genotype most related to cases of granulomatous amoebic
encephalitis (GAE) in immunocompromised patients and of keratitis in contact lens wearers …

Morphological Description of the Early Events during the Invasion of Acanthamoeba castellanii Trophozoites in a Murine Model of Skin Irradiated under UV-B Light

M Hernández-Jasso, D Hernández-Martínez… - Pathogens, 2020 - mdpi.com
Skin infections have been associated with Acanthamoeba, nevertheless the events during
skin invasion and UV-B light effects on it are unknown. The early morphological events of …