Per gram of tissue, the kidneys are among our most highly perfused organs. Yet the renal
cortex and, in particular, the renal medulla are susceptible to hypoxia. In turn, hypoxia is a …

Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence
suggests that CKD aggravates renal hypoxia, and in turn, renal hypoxia accelerates CKD …

Our kidneys receive about one-fifth of the cardiac output at rest and have a low oxygen
extraction ratio, but may sustain, under some conditions, hypoxic injuries that might lead to …

Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

We develop a pseudo-three-dimensional model of oxygen transport for the renal cortex of
the rat, incorporating both the axial and radial geometry of the preglomerular circulation and …

Chronic kidney disease (CKD) is caused by hypoxia in the renal tissue, leading to
inflammation and increased migration of pathogenic cells. Studies showed that leukocytes …

Functional and structural alterations of peritubular capillaries (PTCs) are a major
determinant of chronic kidney disease (CKD). Using a software-based algorithm for …

Kidney normothermic machine perfusion (NMP) has historically used a 95% O2-5% CO2
gas mixture. Using a porcine model of organ retrieval, NMP, and reperfusion, we tested the …

To assess the physiological significance of arterial-to-venous (AV) oxygen shunting, we
generated a new pseudo-three-dimensional computational model of oxygen diffusion from …

Computational models have made a major contribution to the field of physiology. As the
complexity of our understanding of biological systems expands, the need for computational …